PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v3.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT1G67970.1
Common NameAT-HSFA8, HSF03, HSF5, HSFA8, T23K23.18
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family HSF
Protein Properties Length: 374aa    MW: 42629.9 Da    PI: 4.5775
Description heat shock transcription factor A8
Gene Model
Gene Model ID Type Source Coding Sequence
AT1G67970.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HSF_DNA-bind105.64e-33201122102
                   HHHHHHHHHCTGGGTTTSEES.SSSSEEEES-HHHHHHHTHHHHSTT--HHHHHHHHHHTTEEE---SSBTTTTXTTSEEEEESXXXXXXXXXXXXX CS
  HSF_DNA-bind   2 Flkklyeiledeelkelisws.engnsfvvldeeefakkvLpkyFkhsnfaSFvRQLnmYgFkkvkdeekkskskekiweFkhksFkkgkkelleki 97 
                   Fl+k y++++d++++++isws +  nsfv+ld++ f+ ++LpkyFkhsnf+SF+RQLn+YgF+kv+ ++         weF+++ F +g+k+ll+++
   AT1G67970.1  20 FLRKCYDMVDDSTTDSIISWSpSADNSFVILDTTVFSVQLLPKYFKHSNFSSFIRQLNIYGFRKVDADR---------WEFANDGFVRGQKDLLKNV 107
                   9********************8888*****************************************999.........******************9 PP

                   XXXXX CS
  HSF_DNA-bind  98 krkks 102
                    r+k+
   AT1G67970.1 108 IRRKN 112
                   99987 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.109.4E-3512105IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.77E-3115110IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM004159.2E-5416110IPR000232Heat shock factor (HSF)-type, DNA-binding
PRINTSPR000564.8E-192043IPR000232Heat shock factor (HSF)-type, DNA-binding
PfamPF004471.2E-2820110IPR000232Heat shock factor (HSF)-type, DNA-binding
PRINTSPR000564.8E-195971IPR000232Heat shock factor (HSF)-type, DNA-binding
PROSITE patternPS0043406084IPR000232Heat shock factor (HSF)-type, DNA-binding
PRINTSPR000564.8E-197284IPR000232Heat shock factor (HSF)-type, DNA-binding
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005737Cellular Componentcytoplasm
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0043565Molecular Functionsequence-specific DNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000013anatomycauline leaf
PO:0000037anatomyshoot apex
PO:0000084anatomyplant sperm cell
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009005anatomyroot
PO:0009006anatomyshoot system
PO:0009009anatomyplant embryo
PO:0009010anatomyseed
PO:0009025anatomyvascular leaf
PO:0009029anatomystamen
PO:0009030anatomycarpel
PO:0009031anatomysepal
PO:0009032anatomypetal
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0009052anatomyflower pedicel
PO:0020030anatomycotyledon
PO:0020038anatomypetiole
PO:0020100anatomyhypocotyl
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0025195anatomypollen tube cell
PO:0025281anatomypollen
PO:0001017developmental stageM germinated pollen stage
PO:0001054developmental stagevascular leaf senescent stage
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0001185developmental stageplant embryo globular stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 374 aa     Download sequence    Send to blast
MVKSTDGGGG SSSSSSVAPF LRKCYDMVDD STTDSIISWS PSADNSFVIL DTTVFSVQLL  60
PKYFKHSNFS SFIRQLNIYG FRKVDADRWE FANDGFVRGQ KDLLKNVIRR KNVQSSEQSK  120
HESTSTTYAQ EKSGLWKEVD ILKGDKQVLA QELIKVRQYQ EVTDTKMLHL EDRVQGMEES  180
QQEMLSFLVM VMKNPSLLVQ LLQPKEKNTW RKAGEGAKIV EEVTDEGESN SYGLPLVTYQ  240
PPSDNNGTAK SNSNDVNDFL RNADMLKFCL DENHVPLIIP DLYDDGAWEK LLLLSPSRKK  300
TKKQENIVKK GKDDLTLEEE EEDGTMELDK SYMLKLISEE MEKPDDFEFG QLTPERSRNL  360
EILTEQMELL ASNE
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5d5u_B3e-26811017129Heat shock factor protein 1
5d5v_B3e-26811017129Heat shock factor protein 1
5d5v_D3e-26811017129Heat shock factor protein 1
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.59720.0flower| leaf
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO306976040.0
Genevisible259992_at0.0
Expression AtlasAT1G67970-
AtGenExpressAT1G67970-
ATTED-IIAT1G67970-
Functional Description ? help Back to Top
Source Description
TAIRmember of Heat Stress Transcription Factor (Hsf) family
UniProtTranscriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE).
Function -- GeneRIF ? help Back to Top
  1. HSFA8 functions as redox sensing transcription factor within the stress-responsive transcriptional network.
    [PMID: 25666709]
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT1G67970.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT1G67970
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAJ2518660.0AJ251866.1 Arabidopsis thaliana mRNA for heat shock factor 5 (hsf5 gene).
GenBankAY0943960.0AY094396.1 Arabidopsis thaliana At1g67970/T23K23_18 mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_176964.10.0heat stress transcription factor A-8
SwissprotQ9S7U50.0HSFA8_ARATH; Heat stress transcription factor A-8
TrEMBLD7KW840.0D7KW84_ARALL; Predicted protein
STRINGAT1G67970.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM70452637
Representative plantOGRP1084768
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  2. Nover L, et al.
    Arabidopsis and the heat stress transcription factor world: how many heat stress transcription factors do we need?
    Cell Stress Chaperones, 2001. 6(3): p. 177-89
    [PMID:11599559]
  3. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
    [PMID:14593172]
  4. Hass C, et al.
    The response regulator 2 mediates ethylene signalling and hormone signal integration in Arabidopsis.
    EMBO J., 2004. 23(16): p. 3290-302
    [PMID:15282545]
  5. Truman W,de Zabala MT,Grant M
    Type III effectors orchestrate a complex interplay between transcriptional networks to modify basal defence responses during pathogenesis and resistance.
    Plant J., 2006. 46(1): p. 14-33
    [PMID:16553893]
  6. Ma S,Bohnert HJ
    Integration of Arabidopsis thaliana stress-related transcript profiles, promoter structures, and cell-specific expression.
    Genome Biol., 2007. 8(4): p. R49
    [PMID:17408486]
  7. Chawade A,Br
    Putative cold acclimation pathways in Arabidopsis thaliana identified by a combined analysis of mRNA co-expression patterns, promoter motifs and transcription factors.
    BMC Genomics, 2007. 8: p. 304
    [PMID:17764576]
  8. Guo J, et al.
    Genome-wide analysis of heat shock transcription factor families in rice and Arabidopsis.
    J Genet Genomics, 2008. 35(2): p. 105-18
    [PMID:18407058]
  9. Ascencio-Ib
    Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.
    Plant Physiol., 2008. 148(1): p. 436-54
    [PMID:18650403]
  10. Charron JB,Ouellet F,Houde M,Sarhan F
    The plant Apolipoprotein D ortholog protects Arabidopsis against oxidative stress.
    BMC Plant Biol., 2008. 8: p. 86
    [PMID:18671872]
  11. Wang Y, et al.
    Transcriptome analyses show changes in gene expression to accompany pollen germination and tube growth in Arabidopsis.
    Plant Physiol., 2008. 148(3): p. 1201-11
    [PMID:18775970]
  12. Shin R,Jez JM,Basra A,Zhang B,Schachtman DP
    14-3-3 proteins fine-tune plant nutrient metabolism.
    FEBS Lett., 2011. 585(1): p. 143-7
    [PMID:21094157]
  13. Giesguth M,Sahm A,Simon S,Dietz KJ
    Redox-dependent translocation of the heat shock transcription factor AtHSFA8 from the cytosol to the nucleus in Arabidopsis thaliana.
    FEBS Lett., 2015. 589(6): p. 718-25
    [PMID:25666709]